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apalutamide will decrease the level or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with prescription drugs that are CYP2C19 substrates can lead to reduced publicity to these medications.ceritinib will enhance the level or result of